LIU Mei Hui

Dr. Liu Meihui
Lecturer 
Department of Chemistry 
Food Science & Technology Programme

Tel: (65) 6516 3523
Fax: (65) 6775 7895
Room: S16-09-03
Email: chmlmh@nus.edu.sg

 

Qualifications

BSc (Hons), National University of Singapore, Food Science and Technology, 2003;  Ph.D. , National  University of Singapore (Molecular Biology), 2007; Visiting Fellow, Cornell University, 2010; Postdoctoral Fellow, Genome Institute of Singapore, 2007-2013
A*STAR Graduate Scholar (2004); A*STAR Postdoctoral Fellow (2010)

Research Areas:

  1. Molecular Nutrition- Diet induced transcription regulation of Nuclear Receptors, their co-regulators and non-coding RNAs in clinically relevant pathways using Genomics and Molecular approaches
  2. Nutrigenetics- Modulation of individual susceptibility to insulin resistance
  3. Nutrigenomics- Stratified nutritional strategies for the Asian population

Publications:


1. Loy CJ, Evelyn S, Lim FK, Liu MH, Yong EL. Growth dynamics of human leiomyoma cells and inhibitory effects of the peroxisome proliferator-activated receptor-γ ligand, pioglitazone. Molecular Human Reproduction (UK). 2005; 11:561-566

2. Shen P, Liu MH, Ng TY, Chan YH, Yong EL. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARα, PPARγ, and adipocyte differentiation in vitro. Journal of Nutrition. 2006; 136(4):899-905

3. Liu MH, Li J, Shen P, Tai ES, Yong EL. A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin. Molecular Endocrinology. 2008; 22(5):1078-1092

4. Yong EL, Li J, Liu MH. Single gene contributions: genetic variants of peroxisome proliferator-activated receptor (isoforms alpha, beta/delta and gamma) and mechanisms of dyslipidemias. Current Opinion in Lipidology. 2008; 19(2): 106- 112

5. Pan YF, Wansa KD, Liu MH, Zhao B, Hong SZ, Tan PY, Lim KS, Bourque G, Liu ET, Cheung E. Regulation of estrogen receptor-mediated long range transcription via evolutionarily conserved distal response elements. Journal of Biological Chemistry. 2008; 283(47): 32977- 32988

6. Fullwood MJ, Liu MH, Pan YF et al. The Estrogen Receptor α-bound Human Chromatin Interactome. Nature. 2009; 462(7269): 58-64

7. Mason CE, Shu FJ, Wang C, Session RM, Kallen RG, Sidell N, Yu T, Liu MH, Cheung E, Kallen CB. Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements. Nucleic Acids Research. 2010; 38(7):2355-2368

8. Liu MH & Cheung E. Book chapter: Systems biology of Nuclear Hormone signalling and gene regulation. Signaling, Gene Regulation and Cancer. Nova Publishers.