Associate Director Center for Teaching, Learning and Technology
TEL: (65) 6516 3523
FAX: (65) 6775 7895
ROOM: S14-06-04
EMAIL: fstlmh@nus.edu.sg
Qualifications
Visiting Fellow, Cornell University, USA, 2010
Postdoctoral Fellow, Genome Institute of Singapore, Singapore, 2007-2013
Doctor of Philosophy, National University of Singapore (Molecular Biology), 2007
Bachelor of Science (Honours), National University of Singapore (Food Science & Technology), 2003
Awards
2024 National Day Award, The Commendation Medal
2022, 2023, 2024 Annual Teaching Excellence Award
2016, 2018, 2021, 2022, 2023 Faculty Teaching Excellence Award
2023 FoS Academic Mentorship Award
2018, 2023 Long Service Award
Research Areas
Mechanisms of Individual Variability:
Clinical studies on personalised nutritional strategies to control glycemic response
Modulation of individual susceptibility to insulin resistance using human myotube models
Mechanisms of bioactives in food products:
Effects of bioactives eg. anthocyanins in clinically or physiologically relevant pathways using genomics and molecular approaches
Novel food products and technologies:
Validation of efficacy in clinical trials
Microfludics for food production
Teaching Pedagogies
Peer Feedback mechanisms
Learning in blended environments
Previous Appointments
Assistant Dean (Undergraduate Studies & Student Life)
Publications
Zhang Z, Chng KR, Lingadahalli S, Chen Z, Liu MH, Do HH, Cai S, Rinaldi N, Poh HM, Li G, Sung YY, Heng CL, Core LJ, Tan SK, Ruan X, Lis JT, Kellis M, Ruan Y, Sung WK, Cheung E. An AR-ERG transcriptional signature defined by long-range chromatin interactomes in prostate cancer cells. Genome Research. 2019 Feb;29(2):223-235.
Tan ALM, Langley SR, Tan CF, Chai JF, Khoo CM, Leow MK, Khoo EYH, Moreno-Moral A, Pravenec M, Rotival M, Sadananthan SA, Velan SS, Venkataraman K, Chong YS, Lee YS, Sim X, Stunkel W, Liu MH, Tai ES, Petretto E. Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore. Journal of Clinical Endocrinology & Metabolism. 2019 Feb 1;104(2):465-486.
LoKA, Huang S, Walet ACE, Zhang Z, Leow MK, Liu MH, Sun L. Adipocyte Long Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-leptin Which Regulates Leptin. Diabetes 2018 67(6): 1045-1056
Liu MH, Cheung E. Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer. Molecular and Cellular Endocrinology. 2013; doi:pii: S0303-7207(13)
Mason CE, Shu FJ, Wang C, Session RM, Kallen RG, Sidell N, Yu T, Liu MH, Cheung E, Kallen CB. Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements. Nucleic Acids Research. 2010; 38(7):2355-2368
Fullwood MJ, Liu MH, Pan YF et al. The Estrogen Receptor a-bound Human Chromatin Interactome. Nature. 2009; 462(7269): 58-64
Pan YF, Wansa KD, Liu MH, Zhao B, Hong SZ, Tan PY, Lim KS, Bourque G, Liu ET, Cheung E. Regulation of estrogen receptor-mediated long range transcription via evolutionarily conserved distal response elements. Journal of Biological Chemistry. 2008; 283(47): 32977- 32988
Yong EL, Li J, Liu MH. Single gene contributions: genetic variants of peroxisome proliferator-activated receptor (isoforms alpha, beta/delta and gamma) and mechanisms of dyslipidemias. Current Opinion in Lipidology. 2008; 19(2): 106- 112
Liu MH, Li J, Shen P, Tai ES, Yong EL. A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin. Molecular Endocrinology. 2008; 22(5):1078-1092
Shen P, Liu MH, Ng TY, Chan YH, Yong EL. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARα, PPARγ, and adipocyte differentiation in vitro. Journal of Nutrition. 2006; 136(4):899-905
